原创力文档post mortem magnetic resonance imaging in the fetus, infant and child a comparative study with conventional autopsy (marias protocol)事后剖析胎儿磁共振成像,婴儿和儿童比较研究与常规解剖(marias协议).pdfVIP
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post mortem magnetic resonance imaging in the fetus, infant and child a comparative study with conventional autopsy (marias protocol)事后剖析胎儿磁共振成像,婴儿和儿童比较研究与常规解剖(marias协议)
Thayyil et al. BMC Pediatrics 2011, 11:120
/1471-2431/11/120
STUDY PROTOCOL Open Access
Post mortem magnetic resonance imaging in the
fetus, infant and child: A comparative study with
conventional autopsy (MaRIAS Protocol)
1* 2 2 3 4 4 5
Sudhin Thayyil , Neil J Sebire , Lyn S Chitty , Angie Wade , Oystein Olsen , Roxana S Gunny , Amaka Offiah ,
4 4 4 1 6
Dawn E Saunders , Catherine M Owens , WK ‘Kling’ Chong , Nicola J Robertson and Andrew M Taylor
Abstract
Background: Minimally invasive autopsy by post mortem magnetic resonance (MR) imaging has been suggested
as an alternative for conventional autopsy in view of the declining consented autopsy rates. However, large
prospective studies rigorously evaluating the accuracy of such an approach are lacking. We intend to compare the
accuracy of a minimally invasive autopsy approach using post mortem MR imaging with that of conventional
autopsy in fetuses, newborns and children for detection of the major pathological abnormalities and/or
determination of the cause of death.
Methods/Design: We recruited 400 consecutive fetuses, newborns and children referred for conventional autopsy to
one of the two participating hospitals over a three-year period. We acquired whole body post mortem MR imaging
using a 1.5 T MR scanner (Avanto, Siemens Medical Solutions, Enlargen, Germany) prior to autopsy. The total scan time
varied between 90 to 120 minutes. Each MR image was reported by a team of four specialist radiologists (paediatric
neuroradiology, paediatric cardiology, paediatric chest abdominal imaging and musculoskele
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