post-exposure prophylaxis for siv revisited animal model for hiv prevention接触后预防siv重新审视预防艾滋病毒的动物模型.pdfVIP
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post-exposure prophylaxis for siv revisited animal model for hiv prevention接触后预防siv重新审视预防艾滋病毒的动物模型
AIDS Research and Therapy BioMed Central
Research Open Access
Post-exposure prophylaxis for SIV revisited: Animal model for HIV
prevention
Peter Emau*, Yonghou Jiang, Michael B Agy, Baoping Tian, Girma Bekele and
Che-Chung Tsai
Address: Washington National Primate Research Center, University of Washington, Box 357330 Health Sciences Building, Seattle, Washington
98195, USA
Email: Peter Emau* - pemau@; Yonghou Jiang - yhjiang@;
Michael B Agy - magy@; Baoping Tian - baoping@;
Girma Bekele - girma@; Che-Chung Tsai - cctsai@
* Corresponding author
Published: 28 November 2006 Received: 29 August 2006
Accepted: 28 November 2006
AIDS Research and Therapy 2006, 3:29 doi:10.1186/1742-6405-3-29
This article is available from: /content/3/1/29
© 2006 Emau et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine
(PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection
in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective
if treatment is delayed or duration of treatment is shortened. Critical factors for efficacy include timing
and duration of treatment, potency of antiretroviral drug and a
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