plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice血浆和组织α-tocopherol浓度和δ-tocopherol高剂量小鼠膳食补充.pdfVIP

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plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice血浆和组织α-tocopherol浓度和δ-tocopherol高剂量小鼠膳食补充.pdf

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plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice血浆和组织α-tocopherol浓度和δ-tocopherol高剂量小鼠膳食补充

Nutrients 2012, 4, 467-490; doi:10.3390/nu4060467 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Article Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice 1 2 2 1 3 Laura L. Baxter , Juan J. Marugan , Jingbo Xiao , Art Incao , John C. McKew , Wei Zheng 3,* and William J. Pavan 1 1 Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA; E-Mails: lbaxter@ (L.L.B.); aincao@ (A.I.); bpavan@ (W.J.P.) 2 Probe Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA; E-Mails: maruganj@ (J.J.M.); xiaoj@ (J.X.) 3 Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA; E-Mail: john.mckew@ * Author to whom correspondence should be addressed; E-Mail: wzheng@; Tel.: +1-301-827-6727; Fax: +1-301-217-5728. Received: 29 March 2012; in revised form: 25 May 2012 / Accepted: 29 May 2012 / Published: 6 June 2012 Abstract: Vitamin E isoforms are essential nutrients that are widely used as dietary supplements and therapeutic agents for a variety of diseases. However, their pharmacokinetic (PK) properties remain poorly characterized, and high dosage animal stu