plant micrornas and their role in defense against viruses a bioinformatics approach植物小分子核糖核酸和他们的角色在防御病毒生物信息学方法.pdfVIP
- 1、本文档共12页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
plant micrornas and their role in defense against viruses a bioinformatics approach植物小分子核糖核酸和他们的角色在防御病毒生物信息学方法
Pérez-Quintero et al. BMC Plant Biology 2010, 10:138
/1471-2229/10/138
R E S E A R C H A R T I C L E Open Access
Research article
Plant microRNAs and their role in defense against
viruses: a bioinformatics approach
Álvaro L Pérez-Quintero, Rafik Neme, Andrés Zapata and Camilo López*
Abstract
Background: microRNAs (miRNAs) are non-coding short RNAs that regulate gene expression in eukaryotes by
translational inhibition or cleavage of complementary mRNAs. In plants, miRNAs are known to target mostly
transcription factors and are implicated in diverse aspects of plant growth and development. A role has been
suggested for the miRNA pathway in antiviral defense in plants. In this work, a bioinformatics approach was taken to
test whether plant miRNAs from six species could have antiviral activity by targeting the genomes of plant infecting
viruses.
Results: All plants showed a repertoire of miRNAs with potential for targeting viral genomes. The viruses were targeted
by abundant and conserved miRNA families in regions coding for cylindrical inclusion proteins, capsid proteins, and
nuclear inclusion body proteins. The parameters for our predicted miRNA:target pairings in the viral genomes were
similar to those for validated targets in the plant genomes, indicating that our predicted pairings might behave in-vivo
as natural miRNa-target pairings. Our screening was compared with negative controls comprising randomly generated
miRNAs, animal miRNAs, and genomes of animal-infecting viruses. We found that plant miRNAs target plant viruses
more efficiently than any other sequences, but also, miRNAs can either preferentially target plant-infecting viruses or
target any virus without preference.
Conclusions: Our results show a strong potential for antiviral activity of plant miRNAs and suggest that the miRNA
pathway may be a supp
您可能关注的文档
- phases-of-illness paradigm better communication, better outcomesphases-of-illness模式更好的沟通,更好的结果.pdf
- pharyngeal oxygen administration increases the time to serious desaturation at intubation in acute lung injury an experimental study咽氧气政府增加时间严重稀释在插管在急性肺损伤的实验研究.pdf
- phase ii trial of isotonic fluid resuscitation in kenyan children with severe malnutrition and hypovolaemia二期试验等渗液体复苏在肯尼亚儿童严重营养不良和hypovolaemia.pdf
- ph-based detection of phenylalnine by potentiometric and colorimetric methods的phenylalnine ph-based检测电位和比色方法.pdf
- phenolic and lignan glycosides from the butanol extract of averrhoa carambola l. root丁醇提取的酚醛和木酚素苷averrhoa杨桃l .根.pdf
- phenolic alkaloids from menispermum dauricum rhizome protect against brain ischemia injury via regulation of glt-1, eaac1 and ros generation酚类生物碱从menispermum dauricum粉末通过监管glt-1预防脑缺血损伤,eaac1和ros生成.pdf
- phcocl-pybasic alumina as a versatile reagent for benzoylation in solvent-free conditionsphcocl-pybasic氧化铝作为一个通用的苯甲酰化试剂在无溶剂的条件下.pdf
- phase-segregated dendrigraft copolymer architecturesphase-segregated dendrigraft共聚物体系结构.pdf
- phenolic antioxidants identified by esi-ms from yerba maté (ilex paraguariensis) and green tea (camelia sinensis) extracts从巴拉圭茶酚类抗氧化剂被谱(冬青属paraguariensis)和绿茶提取物(卡梅利娅sinensis).pdf
- phase-modulated waveform design for extended target detection in the presence of clutter相位调制波形设计的扩展目标探测的杂乱.pdf
- 概念物理郑zaijun课件汇01introduction.pdf
- starter3课程名词自行车当您骑时会运动腿部肌肉单词.pdf
- 中考英语试题版片.pdf
- 一章android概述课件-btc.pdf
- jetstar flight itinerary for booking ref te8nnd jq508捷星航空行程预订参考RefTe8nndJQ508.pdf
- 宜居城市郊区claremont manor-melbourne销售手册.pdf
- 绝望主妇desperate housewives s01e简体英文.pdf
- 今天主要任务项目model层进行升级为核心基础dayphp.pdf
- 个医学病毒学病毒感染发病机理在微生物学过程中医疗计划级sysuinfection and pathogenesis.pdf
- 新人教版级下册同步练习答案及.pdf
最近下载
- 《HJT367-2007-环境保护产品技术要求电磁管道流量计》.pdf VIP
- 2025诗词大会题库(含答案).pdf VIP
- 2025年《老年心理护理实务》课程标准(含课程思政元素).docx VIP
- 中外教育名著选读复习课程.ppt VIP
- GB50586-2010 铝母线焊接工程施工及验收规范.docx VIP
- 医院内静脉血栓栓塞症防治手册.docx VIP
- 小家电安规基本知识培训.pptx VIP
- 财务自由之路.doc VIP
- SW7203数据手册_V13926596180高效率双向升降压.pdf VIP
- 通过同品种医疗器械临床试验或临床使用获得的数据进行的分析评价报告.pdf VIP
文档评论(0)