plant micrornas and their role in defense against viruses a bioinformatics approach植物小分子核糖核酸和他们的角色在防御病毒生物信息学方法.pdfVIP
- 1、本文档共12页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
plant micrornas and their role in defense against viruses a bioinformatics approach植物小分子核糖核酸和他们的角色在防御病毒生物信息学方法
Pérez-Quintero et al. BMC Plant Biology 2010, 10:138
/1471-2229/10/138
R E S E A R C H A R T I C L E Open Access
Research article
Plant microRNAs and their role in defense against
viruses: a bioinformatics approach
Álvaro L Pérez-Quintero, Rafik Neme, Andrés Zapata and Camilo López*
Abstract
Background: microRNAs (miRNAs) are non-coding short RNAs that regulate gene expression in eukaryotes by
translational inhibition or cleavage of complementary mRNAs. In plants, miRNAs are known to target mostly
transcription factors and are implicated in diverse aspects of plant growth and development. A role has been
suggested for the miRNA pathway in antiviral defense in plants. In this work, a bioinformatics approach was taken to
test whether plant miRNAs from six species could have antiviral activity by targeting the genomes of plant infecting
viruses.
Results: All plants showed a repertoire of miRNAs with potential for targeting viral genomes. The viruses were targeted
by abundant and conserved miRNA families in regions coding for cylindrical inclusion proteins, capsid proteins, and
nuclear inclusion body proteins. The parameters for our predicted miRNA:target pairings in the viral genomes were
similar to those for validated targets in the plant genomes, indicating that our predicted pairings might behave in-vivo
as natural miRNa-target pairings. Our screening was compared with negative controls comprising randomly generated
miRNAs, animal miRNAs, and genomes of animal-infecting viruses. We found that plant miRNAs target plant viruses
more efficiently than any other sequences, but also, miRNAs can either preferentially target plant-infecting viruses or
target any virus without preference.
Conclusions: Our results show a strong potential for antiviral activity of plant miRNAs and suggest that the miRNA
pathway may be a supp
您可能关注的文档
- phases-of-illness paradigm better communication, better outcomesphases-of-illness模式更好的沟通,更好的结果.pdf
- pharyngeal oxygen administration increases the time to serious desaturation at intubation in acute lung injury an experimental study咽氧气政府增加时间严重稀释在插管在急性肺损伤的实验研究.pdf
- phase ii trial of isotonic fluid resuscitation in kenyan children with severe malnutrition and hypovolaemia二期试验等渗液体复苏在肯尼亚儿童严重营养不良和hypovolaemia.pdf
- ph-based detection of phenylalnine by potentiometric and colorimetric methods的phenylalnine ph-based检测电位和比色方法.pdf
- phenolic and lignan glycosides from the butanol extract of averrhoa carambola l. root丁醇提取的酚醛和木酚素苷averrhoa杨桃l .根.pdf
- phenolic alkaloids from menispermum dauricum rhizome protect against brain ischemia injury via regulation of glt-1, eaac1 and ros generation酚类生物碱从menispermum dauricum粉末通过监管glt-1预防脑缺血损伤,eaac1和ros生成.pdf
- phcocl-pybasic alumina as a versatile reagent for benzoylation in solvent-free conditionsphcocl-pybasic氧化铝作为一个通用的苯甲酰化试剂在无溶剂的条件下.pdf
- phase-segregated dendrigraft copolymer architecturesphase-segregated dendrigraft共聚物体系结构.pdf
- phenolic antioxidants identified by esi-ms from yerba maté (ilex paraguariensis) and green tea (camelia sinensis) extracts从巴拉圭茶酚类抗氧化剂被谱(冬青属paraguariensis)和绿茶提取物(卡梅利娅sinensis).pdf
- phase-modulated waveform design for extended target detection in the presence of clutter相位调制波形设计的扩展目标探测的杂乱.pdf
最近下载
- 初中英语课外阅读黑布林版汤姆叔叔的小屋中文译文.docx VIP
- 路灯安全监理细则.docx VIP
- 凉山州防汛抗旱急预案(修订稿).doc VIP
- 脐带间充质干细向脂肪细胞诱导分化的实验研究.pdf VIP
- 工程地质勘察技术(题库).pdf VIP
- 500110-高职铁道信号自动控制专业教学标准.pdf VIP
- DL∕T 1432.4-2017 变电设备在线监测装置检验规范 第4部分:气体绝缘金属封闭开关设备局部放电特高频在线监测装置.docx VIP
- DO3000系列门机调试(1).doc VIP
- 凉山州防汛抗应急预案(修订稿).doc VIP
- 干部队伍管理能力系统化培养方案.docx VIP
文档评论(0)