phenolic alkaloids from menispermum dauricum rhizome protect against brain ischemia injury via regulation of glt-1, eaac1 and ros generation酚类生物碱从menispermum dauricum粉末通过监管glt-1预防脑缺血损伤,eaac1和ros生成.pdfVIP

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phenolic alkaloids from menispermum dauricum rhizome protect against brain ischemia injury via regulation of glt-1, eaac1 and ros generation酚类生物碱从menispermum dauricum粉末通过监管glt-1预防脑缺血损伤,eaac1和ros生成.pdf

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phenolic alkaloids from menispermum dauricum rhizome protect against brain ischemia injury via regulation of glt-1, eaac1 and ros generation酚类生物碱从menispermum dauricum粉末通过监管glt-1预防脑缺血损伤,eaac1和ros生成

Molecules 2012, 17, 2725-2737; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Phenolic Alkaloids from Menispermum dauricum Rhizome Protect against Brain Ischemia Injury via Regulation of GLT-1, EAAC1 and ROS Generation Bo Zhao 1, Yang Chen 1, Xi Sun 2, Mei Zhou 1, Jie Ding 1, Jin-Jin Zhan 1 and Lian-Jun Guo 1,* 1 Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; E-Mails: cbush2004@163.com (B.Z.); yangchentjyl@163.com (Y.C.); meizhoutjyl@126.com (M.Z.); dingjietjyl@163.com (J.D.); jinjinzhantjyl@126.com (J.-J.Z.) 2 Department of Pharmaceutical Analysis, Drugs Control Centre, Yichang 443002, China; E-Mail: xisunycyj@126.com * Author to whom correspondence should be addressed; E-Mail: lianjunguoyl@163.com; Tel.: +86-27-8369-1762; Fax: +86-27-8369-2602. Received: 13 December 2011; in revised form: 24 February 2012 / Accepted: 28 February 2012 / Published: 6 March 2012 Abstract: Menispermum dauricum rhizome has been widely used in China to treat various cardiovascular and thrombosis disorders. Some studies have reported that the phenolic alkaloids of Menispermum dauricum rhizome (PAM) have protective effects against brain ischemia injury, but the mechanism of this action remains to be clarified. In the present study, we investigated the possible mechanisms of action of PAM on experimental brain ischemia injury. Oxygen and glucose deprivation (OGD) in rat primary cortical cultures and middle cerebral artery oc