plant-derived antimalarial agents new leads and efficient phytomedicines. part ii. non-alkaloidal natural products植物的抗疟药物新线索和高效的植物学期刊。.pdfVIP

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plant-derived antimalarial agents new leads and efficient phytomedicines. part ii. non-alkaloidal natural products植物的抗疟药物新线索和高效的植物学期刊。.pdf

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plant-derived antimalarial agents new leads and efficient phytomedicines. part ii. non-alkaloidal natural products植物的抗疟药物新线索和高效的植物学期刊。

Molecules 2009, 14, 3037-3072; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Plant-Derived Antimalarial Agents: New Leads and Efficient Phytomedicines. Part II. Non-Alkaloidal Natural Products Ronan Batista 1,*, Ademir de Jesus Silva Júnior 1 and Alaíde Braga de Oliveira 2 1 Departamento de Estudos Básicos e Instrumentais, Universidade Estadual do Sudoeste da Bahia – UESB, BR 415, Km 03, s/nº, 45.700-000 Itapetinga, BA, Brazil; E-mail: ademirjr18@.br (A.d.J.S.J.) 2 Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil; E-mail: alaidebraga@.br (A.B.d.O.) * Author to whom correspondence should be addressed; E-mail: ronbatis2004@ Received: 9 July 2009; in revised form: 7 August 2009 / Accepted: 13 August 2009 / Published: 13 August 2009 Abstract: Malaria is still the most destructive and dangerous parasitic infection in many tropical and subtropical countries. The burden of this disease is getting worse, mainly due to the increasing resistance of Plasmodium falciparum against the widely available antimalarial drugs. There is an urgent need for new, more affordable and accessible antimalarial agents possessing original modes of action. Natural products have played a dominant role in the discovery of leads for the development of drugs to treat human diseases, and this fact anticipates