possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder可能去甲肾上腺素转运蛋白多态性的影响在儿童注意力缺陷多动症methylphenidate-induced神经心理功能的变化.pdfVIP

Park et al. Behavioral and Brain Functions 2012, 8:22 /content/8/1/22 RESEARCH Open Access Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder 1 1 2 1 1 1 Subin Park , Jae-Won Kim , Young-Hui Yang , Soon-Beom Hong , Min-Hyeon Park , Boong-Nyun Kim , 1 3 1,4* Min-Sup Shin , Hee-Jeong Yoo and Soo-Churl Cho Abstract Background: Dysregulation of noradrenergic system may play important roles in pathophysiology of attention-deficit/hyperactivity disorder (ADHD). We examined the relationship between polymorphisms in the norepinephrine transporter SLC6A2 gene and attentional performance before and after medication in children with ADHD. Methods: Fifty-three medication-naïve children with ADHD were genotyped and evaluated using the continuous performance test (CPT). After 8-weeks of methylphenidate treatment, these children were evaluated by CPT again. We compared the baseline CPT measures and the post-treatment changes in the CPT measures based on the G1287A and the A-3081T polymorphisms of SLC6A2. Results: There was no significant difference in the baseline CPT measures associated with the G1287A or A-3081T polymorphisms. After medication, however, ADHD subjects with the G/G genotype at the G1287A polymorphism showed a greater decrease in the mean omission error scores (p = 0.006) than subjects with the G/A or A/A genotypes, and subjects with the T allele at the A-3081T polymorphism (T/T or A/T) showed a greater decrease in the mean commission error scores (p = 0.003) than those with the A/A genotypes. Conclusions: