possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder可能去甲肾上腺素转运蛋白多态性的影响在儿童注意力缺陷多动症methylphenidate-induced神经心理功能的变化.pdfVIP
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possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder可能去甲肾上腺素转运蛋白多态性的影响在儿童注意力缺陷多动症methylphenidate-induced神经心理功能的变化
Park et al. Behavioral and Brain Functions 2012, 8:22
/content/8/1/22
RESEARCH Open Access
Possible effect of norepinephrine transporter
polymorphisms on methylphenidate-induced
changes in neuropsychological function in
attention-deficit hyperactivity disorder
1 1 2 1 1 1
Subin Park , Jae-Won Kim , Young-Hui Yang , Soon-Beom Hong , Min-Hyeon Park , Boong-Nyun Kim ,
1 3 1,4*
Min-Sup Shin , Hee-Jeong Yoo and Soo-Churl Cho
Abstract
Background: Dysregulation of noradrenergic system may play important roles in pathophysiology of
attention-deficit/hyperactivity disorder (ADHD). We examined the relationship between polymorphisms in the
norepinephrine transporter SLC6A2 gene and attentional performance before and after medication in children
with ADHD.
Methods: Fifty-three medication-naïve children with ADHD were genotyped and evaluated using the continuous
performance test (CPT). After 8-weeks of methylphenidate treatment, these children were evaluated by CPT again.
We compared the baseline CPT measures and the post-treatment changes in the CPT measures based on the
G1287A and the A-3081T polymorphisms of SLC6A2.
Results: There was no significant difference in the baseline CPT measures associated with the G1287A or A-3081T
polymorphisms. After medication, however, ADHD subjects with the G/G genotype at the G1287A polymorphism
showed a greater decrease in the mean omission error scores (p = 0.006) than subjects with the G/A or A/A
genotypes, and subjects with the T allele at the A-3081T polymorphism (T/T or A/T) showed a greater decrease in
the mean commission error scores (p = 0.003) than those with the A/A genotypes.
Conclusions:
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