primary and secondary autoimmune neutropenia主要和次要自身免疫性中性粒细胞减少.pdfVIP

Arthritis Research Therapy October 2005 Vol 7 No 5 Capsoni et al. Review Primary and secondary autoimmune neutropenia 1 2 3 Franco Capsoni , Piercarlo Sarzi-Puttini and Alberto Zanella 1Rheumatology Unit, Istituto Ortopedico Galeazzi, University of Milan, Milan, Italy 2Rheumatology Unit, Ospedale L Sacco, University of Milan, Milan, Italy 3Hematology Unit, Ospedale Maggiore Policlinico, Fondazione IRCCS, University of Milan, Milan, Italy Corresponding author: Franco Capsoni, franco.capsoni@unimi.it Published: 31 August 2005 Arthritis Research Therapy 2005, 7:208-214 (DOI 10.1186/ar1803) This article is online at /content/7/5/208 © 2005 BioMed Central Ltd Abstract infective diathesis in a neutropenic patient: the speed of Antineutrophil antibodies are well recognized causes of onset and the duration of the neutropenia, the bone marrow neutropenia, producing both quantitative and qualitative defects in myeloid reserves, the absolute circulating monocyte count neutrophils and increased risk for infection. In primary autoimmune and the functional status of phagocytes. neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious infections Immune mediated neutropenias (Table 1) involve a low neutro- and exhibits a self-limited course. Chronic idiopathic neutropenia of phil co