原创力文档preferential regulation of duplicated genes by micrornas in mammals优惠的监管由小分子核糖核酸重复基因在哺乳动物.pdfVIP
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preferential regulation of duplicated genes by micrornas in mammals优惠的监管由小分子核糖核酸重复基因在哺乳动物
Volume 9, Issue 8, Article R132et al.Li2008 Open Access
Research
Preferential regulation of duplicated genes by microRNAs in
mammals
Jingjing Li*†‡, Gabriel Musso*†‡ and Zhaolei Zhang*†‡
Addresses: *Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada. †Donnelly Centre
for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada. ‡Banting and Best
Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada.
Correspondence: Zhaolei Zhang. Email: Zhaolei.Zhang@utoronto.ca
Published: 26 August 2008 Received: 7 March 2008
Revised: 5 July 2008
Genome Biology 2008, 9:R132 (doi:10.1186/gb-2008-9-8-r132)
Accepted: 26 August 2008
The electronic version of this article is the complete one and can be
found online at /2008/9/8/R132
© 2008 Li et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MicroRNAs and duplicated genesregulatory patterns of mammalian paralogs have evolved./ppAnalysis of duplicate genes and predicted microRNA targets in human and mouse shows that microRNAs are important in how the
Abstract
Background: Although recent advances have been made in identifying and analyzing instances of
microRNA-mediated gene regulation, it remains unclear by what mechanisms attenuation of
tran
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