pre-fractionated microbial samples – the second generation natural products library at wyethpre-fractionated微生物样本u2014u2014第二代天然产物库在惠氏.pdfVIP
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pre-fractionated microbial samples – the second generation natural products library at wyethpre-fractionated微生物样本u2014u2014第二代天然产物库在惠氏
Molecules 2008, 13, 1406-1426; DOI: 10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/molecules
Article
Pre-fractionated Microbial Samples – The Second Generation
Natural Products Library at Wyeth
Melissa M. Wagenaar
Natural Products Discovery Research, Chemical and Screening Sciences, Wyeth Research, 401 N.
Middletown Road, Pearl River, New York 10965, USA; E-mail: wagenam@
Received: 30 May 2008 / Accepted: 16 June 2008 / Published: 20 June 2008
Abstract: From the beginning of the antibiotic era in the 1940s to the present, Wyeth has
sustained an active research program in the area of natural products discovery. This
program has continually evolved through the years in order to best align with the “current”
drug discovery paradigm in the pharmaceutical industry. The introduction of high-
throughput screening and the miniaturization of assays have created a need to optimize
natural product samples to better suit these new technologies. Furthermore, natural product
programs are faced with an ever shortening time period from hit detection to lead
characterization. To address these issues, Wyeth has created a pre-fractionated natural
products library using reversed-phase HPLC to complement their existing library of crude
extracts. The details of the pre-fractionated library and a cost-benefit analysis will be
presented in this review.
Keywords: Natural produc
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