原创力文档prostate cancer genomics can we distinguish between indolent and fatal disease using genetic markers前列腺癌基因组学我们能使用遗传标记区分懒惰和致命的疾病.pdfVIP
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prostate cancer genomics can we distinguish between indolent and fatal disease using genetic markers前列腺癌基因组学我们能使用遗传标记区分懒惰和致命的疾病
Wiklund Genome Medicine 2010, 2:45
/content/2/7/45
R E V I E W
Prostate cancer genomics: can we distinguish
between indolent and fatal disease using genetic
markers?
Fredrik Wiklund*
increase with age, with more than 67% of men aged over
Abstract
80 years having prostate cancer at time of death [3].
Prostate cancer is one of the most heritable cancers ese findings indicate that a high proportion of prostate
in men, and recent genome-wide association studies tumors are clinically insignificant and will never lead to a
have revealed numerous genetic variants associated lethal outcome. Furthermore, the introduction and
with disease. The risk variants identied using case- widespread application of prostate-specific antigen (PSA)
control designs that compared unaected individuals testing has led to increased detection of early-stage, low-
with all types of patients with prostate cancer show volume, non-palpable tumors. is has in turn raised
little or no ability to discriminate between indolent concerns of increased overdiagnosis and unnecessary
and fatal forms of this disease. This suggests dierent treatment of indolent disease [4,5]. To this end, new
genetic components are involved in the initiation strategies to help clinicians distinguish between lethal
as compared with the prognosis of prostate cancer. and indolent prostate cancer are urgently needed.
Future studies contrasting patients with more and less Prostate cancer is one of the most heritable ca
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