protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (hiv-1) infected pediatric patients a cross-sectional study蛋白酶抑制剂相关突变妥协的功效治疗人类免疫缺陷病毒- 1(hiv - 1)感染的儿科患者的横断面研究.pdfVIP

AIDS Research and Therapy BioMed Central Research Open Access Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients: a cross-sectional study 1 1 1 Amisha Malhotra* , Sunanda Gaur , Patricia Whitley-Williams , 2 1 Caitlin Loomis and Anna Petrova Address: 1Department of Pediatrics, Division of Infectious Disease, University of Medicine and Dentistry of New Jersey (UMDNJ) – Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA and 2Princeton University, Princeton, New Jersey-08542, USA Email: Amisha Malhotra* - malhotam@; Sunanda Gaur - gaursu@; Patricia Whitley-Williams - whitlepn@; Caitlin Loomis - caitlin.loomis@; Anna Petrova - petroran@ * Corresponding author Published: 9 July 2007 Received: 30 October 2006 Accepted: 9 July 2007 AIDS Research and Therapy 2007, 4:15 doi:10.1186/1742-6405-4-15 This article is available from: /content/4/1/15 © 2007 Malhotra et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mort