原创力文档prostate-specific antigen and hormone receptor expression in male and female breast carcinoma前列腺特异性抗原和激素受体表达在男性和女性的乳腺癌.pdfVIP
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prostate-specific antigen and hormone receptor expression in male and female breast carcinoma前列腺特异性抗原和激素受体表达在男性和女性的乳腺癌
Kraus et al. Diagnostic Pathology 2010, 5:63
/content/5/1/63
RESEARCH Open Access
Prostate-specific antigen and hormone receptor
expression in male and female breast carcinoma
*
Teresa S Kraus , Cynthia Cohen, Momin T Siddiqui
Abstract
Background: Prostate carcinoma is among the most common solid tumors to secondarily involve the male breast.
Prostate specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are expressed in benign and
malignant prostatic tissue, and immunohistochemical staining for these markers is often used to confirm the
prostatic origin of metastatic carcinoma. PSA expression has been reported in male and female breast carcinoma
and in gynecomastia, raising concerns about the utility of PSA for differentiating prostate carcinoma metastasis to
the male breast from primary breast carcinoma. This study examined the frequency of PSA, PSAP, and hormone
receptor expression in male breast carcinoma (MBC), female breast carcinoma (FBC), and gynecomastia.
Methods: Immunohistochemical staining for PSA, PSAP, AR, ER, and PR was performed on tissue microarrays
representing six cases of gynecomastia, thirty MBC, and fifty-six FBC.
Results: PSA was positive in two of fifty-six FBC (3.7%), focally positive in one of thirty MBC (3.3%), and negative in
the five examined cases of gynecomastia. PSAP expression was absent in MBC, FBC, and gynecomastia. Hormone
receptor expression was similar in males and females (AR 74.1% in MBC vs. 67.9% in FBC, p = 0.62; ER 85.2% vs.
68.5%, p = 0.18; and PR 51.9% vs. 48.2%, p = 0.82).
Conclusions: PSA and PSAP are useful markers to distinguish primary breast carcinoma from prostate carcinoma
metastatic to the male breast. Although PSA expression appeared to correlate with hormone receptor expression,
the incidence of PSA expression i
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