原创力文档protective effect of phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats a proteomics analysis保护作用的phellinus linteus多糖提取物对thioacetamide-induced肝纤维化大鼠蛋白质组学分析.pdfVIP
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protective effect of phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats a proteomics analysis保护作用的phellinus linteus多糖提取物对thioacetamide-induced肝纤维化大鼠蛋白质组学分析
Wang et al. Chinese Medicine 2012, 7:23
/content/7/1/23
RESEARCH Open Access
Protective effect of Phellinus linteus
polysaccharide extracts against thioacetamide-
induced liver fibrosis in rats: a proteomics analysis
1 2 2 1 1 3
Hualin Wang , Guang Wu , Hyoung Jin Park , Ping Ping Jiang , Wai-Hung Sit , Leo JLD van Griensven and
Jennifer Man-Fan Wan1*
Abstract
Background: The hepatoprotective potential of Phellinus linteus polysaccharide (PLP) extracts has been described.
However, the molecular mechanism of PLP for the inhibition of liver fibrosis is unclear. This study aims to
investigate the molecular protein signatures involved in the hepatoprotective mechanisms of PLP via a proteomics
approach using a thioacetamide (TAA)-induced liver fibrosis rat model.
Methods: Male Sprague–Dawley rats were divided into three groups of six as follows: Normal group; TAA group, in
which rats received TAA only; and PLP group, in which rats received PLP and TAA. Liver fibrosis was induced in the
rats by repeated intraperitoneal injections of TAA at a dose of 200 mg/kg body weight twice a week for 4 weeks.
PLP was given orally at a dose of 50 mg/kg body weight twice a day from the beginning of the TAA treatment
until the end of the experiment. The development of liver cirrhosis was verified by histological examination. Liver
proteomes were established by two-dimensional gel electrophoresis. Proteins with significantly altered expression
levels were identified by matrix-assisted laser desorption/ionization-time of flight/time of flight mass spectrometry
and the differentially expressed proteins were validated by immunohistochemical staining and reverse transcription
polymerase
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