原创力文档primary investigation of the preparation of nanoparticles by precipitation纳米粒子的制备沉淀的主要调查.pdfVIP
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primary investigation of the preparation of nanoparticles by precipitation纳米粒子的制备沉淀的主要调查
Molecules 2012, 17, 11067-11078; doi:10.3390/molecules170911067
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Primary Investigation of the Preparation of Nanoparticles
by Precipitation
Eliska Vaculikova 1,2,*, Veronika Grunwaldova 3,4, Vladimir Kral 3, Jiri Dohnal 1,5 and
Josef Jampilek 1,5,*
1 Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3,
612 42 Brno, Czech Republic
2 Nanotechnology Centre, VSB—Technical University of Ostrava, 17. listopadu 15/2172,
708 33 Ostrava, Czech Republic
3 Institute of Chemical Technology, Faculty of Chemical Engineering, Technicka 5,
166 28 Prague 6, Czech Republic
4 Institute of Inorganic Chemistry, Academy of Science, 25068 Rez, Czech Republic
5 Research Institute for Pharmacy and Biochemistry, Lidicka 1879/48, 602 00 Brno, Czech Republic
* Authors to whom correspondence should be addressed; E-Mails: eliskavaculikova@seznam.cz (E.V.);
josef.jampilek@ (J.J.); Tel.: +420-541 -562-925 (J.J.); Fax: +420-541-240-607 (J.J.).
Received: 20 August 2012; in revised form: 21 August 2012 / Accepted: 3 September 2012 /
Published: 13 September 2012
Abstract: The absorption, distribution, biotransformation and excretion of a drug involve
its transport across cell membranes. This process is essential and influenced by the
characteristics of the drug, especially its molecular size and shape, solubility at the site of
its absorption, relative lipid solubility, etc. One of the progressive ways for increasing
bioava
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