preferential binding of hif-1 to transcriptionally active loci determines cell-type specific response to hypoxia优惠的绑定hif-1转录活性位点确定特异性对缺氧的反应.pdfVIP

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preferential binding of hif-1 to transcriptionally active loci determines cell-type specific response to hypoxia优惠的绑定hif-1转录活性位点确定特异性对缺氧的反应.pdf

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preferential binding of hif-1 to transcriptionally active loci determines cell-type specific response to hypoxia优惠的绑定hif-1转录活性位点确定特异性对缺氧的反应

Volume 10, Issue 10, Article R113Xia and Kung2009 Open Access Research Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia Xiaobo Xia and Andrew L Kung Address: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Childrens Hospital Boston, and Harvard Medical School, Binney Street, Boston, MA 02115, USA. Correspondence: Andrew L Kung. Email: andrew_kung@ Published: 14 October 2009 Received: 11 June 2009 Revised: 18 September 2009 Genome Biology 2009, 10:R113 (doi:10.1186/gb-2009-10-10-r113) Accepted: 14 October 2009 The electronic version of this article is the complete one and can be found online at /2009/10/10/R113 © 2009 Xia and Kung; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cellular response to hypoxiaactive genes./ppChIP-chip and microarray expression studies show that, in response to hypoxia, HIF-1 preferentially binds to and up-regulates already Abstract Background: Hypoxia-inducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia. To better understand the determinants of HIF-1 binding and transactivation, we used ChIP-chip and gene expression profiling to define the relationship between the epigenetic landscape, sites of HIF- 1 binding, and genes transactivated by hypoxia in two cell lines. Results: We found that when ce