preliminary evidence for obesity-associated insulin resistance in adolescents without elevations of inflammatory cytokines初步证据表明肥胖相关胰岛素抵抗在青少年没有炎性细胞因子的高度.pdfVIP

Cohen et al. Diabetology Metabolic Syndrome 2012, 4:26 DIABETOLOGY /content/4/1/26 METABOLIC SYNDROME RESEARCH Open Access Preliminary evidence for obesity-associated insulin resistance in adolescents without elevations of inflammatory cytokines 1 1,3 1,2,3* Jessica I Cohen , Lawrence Maayan and Antonio Convit Abstract Background: To ascertain whether the associations between obesity, inflammation, and insulin resistance established in human adult studies are found among adolescents. Methods: We contrasted 36 obese and 24 lean youth on fasting glucose, insulin levels, lipid profile, hemoglobin A1C, markers of hepatic function, white blood cell count, C-reactive protein (CRP) and fibrinogen levels. The cytokines IL-6, TNF-α, IFN-γ, IL-10 and IL-4 and the adipokines leptin, resistin, and adiponectin were also compared between the two groups. The fasting glucose and insulin values were used to estimate the degree of insulin resistance with the homeostatic model assessment of insulin resistance (HOMA-IR). T-tests and correlations were run to examine group differences and associations between groups. In addition, regression analyses were used to ascertain whether the markers of inflammation were predictive of the degree of insulin resistance. Results: Although obese adolescents had clear evidence of insulin resistance, only CRP, fibrinogen and leptin were elevated; there were no group differences in pro- or anti-inflammatory cytokines nor adiponectin and resistin. Anthropometric measures of obesity and level of insulin