原创力文档protective effect of salvia miltiorrhiza extract against renal ischemia-reperfusion-induced injury in rats丹参提取物对肾的保护作用ischemia-reperfusion-induced受伤的老鼠.pdfVIP
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protective effect of salvia miltiorrhiza extract against renal ischemia-reperfusion-induced injury in rats丹参提取物对肾的保护作用ischemia-reperfusion-induced受伤的老鼠
Molecules 2012, 17, 1191-1202; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Protective Effect of Salvia miltiorrhiza Extract Against Renal
Ischemia-Reperfusion-Induced Injury in Rats
Gang Chen †, Yunrui Fu † and Xiaohou Wu *
Department of Urology, The First Affiliated Hospital, Chongqing Medical University,
Chongqing 400016, China; E-Mails: gangc4651@ (G.C.); yrfu81@ (Y.F.)
† These authors contributed equally to this work.
* Author to whom correspondence should be addressed; E-Mail: wuxiaohmu54@;
Tel./Fax: +86-23-8901-1121.
Received: 24 December 2011; in revised form: 1 January 2012 / Accepted: 24 January 2012 /
Published: 30 January 2012
Abstract: The present study investigates the effect of pre-treatment with
Salvia miltiorrhiza ethanol extracts (SMEE) on renal function markers, immunity and
antioxidant activities in renal ischemia and reperfusion (IR) rats. Wistar rat kidneys were
subjected to 60 min of global ischemia at 37 °C followed by 30 min of reperfusion, and
were randomly assigned into the sham, IR model and three SMEE-treated groups (n = 8 per
group). Results showed that high serum creatinin (Scr), blood urea nitrogen (BUN),
interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α) and
malondialhehyde (MDA) levels, and low antioxidant enzyme activities were observed in
IR rats compared to the sham rats. Pre-treatment of Salvia miltiorrhiza ethanol extracts for
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