原创力文档protective effects of extracts and flavonoids isolated from scutia buxifolia reissek against chromosome damage in human lymphocytes exposed to hydrogen peroxide保护作用的提取物和黄酮类隔绝scutia buxifolia reissek反对人类淋巴细胞染色体损伤暴露于过氧化氢.pdfVIP
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protective effects of extracts and flavonoids isolated from scutia buxifolia reissek against chromosome damage in human lymphocytes exposed to hydrogen peroxide保护作用的提取物和黄酮类隔绝scutia buxifolia reissek反对人类淋巴细胞染色体损伤暴露于过氧化氢
Molecules 2012, 17, 5757-5769; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Protective Effects of Extracts and Flavonoids Isolated from
Scutia buxifolia Reissek against Chromosome Damage in
Human Lymphocytes Exposed to Hydrogen Peroxide
Aline Augusti Boligon 1,*, Michele Rorato Sagrillo 2,3, Luiz Filipe Machado 3,
3 4 3
Olmiro de Souza Filho , Michel Mansur Machado , Ivana Beatrice Manica da Cruz and
1
Margareth Linde Athayde
1 Program of Post-Graduation in Pharmaceutical Sciences, Federal University of Santa Maria,
Campus Camobi, Santa Maria, RS, 97105-900, Brazil
2 Franciscan University Center – UNIFRA, Andradas Street, 1614, Santa Maria, RS 97010-032, Brazil
3 Program of Post-Graduation in Pharmacology, Federal University of Santa Maria, Campus Camobi,
Santa Maria, RS, 97105-900, Brazil
4 Federal University of Pampa – UNIPAMPA, Uruguaiana, RS 97500-970, Brazil
* Author to whom correspondence should be addressed; E-Mail: alineboligon@;
Tel.: +55-55-3220-9618.
Received: 26 March 2012; in revised form: 25 April 2012 / Accepted: 26 April 2012 /
Published: 14 May 2012
Abstract: Flavonoids are claimed to protect against cardiovascular disease, certain forms
of cancer and ageing, possibly by preventing initial DNA damage. Therefore, we
investigated the protective effects of crude extract, ethyl acetate fraction a
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