protective role of toll-like receptor 3-induced type i interferon in murine coronavirus infection of macrophages保护作用的toll样受体3-induced i型干扰素在小鼠冠状病毒感染的巨噬细胞.pdfVIP

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protective role of toll-like receptor 3-induced type i interferon in murine coronavirus infection of macrophages保护作用的toll样受体3-induced i型干扰素在小鼠冠状病毒感染的巨噬细胞.pdf

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protective role of toll-like receptor 3-induced type i interferon in murine coronavirus infection of macrophages保护作用的toll样受体3-induced i型干扰素在小鼠冠状病毒感染的巨噬细胞

Viruses 2012, 4, 901-923; doi:10.3390/v4050901 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of Macrophages Liudmila Mazaleuskaya 1,2, Rogier Veltrop 1, Nneka Ikpeze 1, Julio Martin-Garcia 1,3 and Sonia Navas-Martin 1,3,* 1 Department of Microbiology and Immunology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA; E-Mails: lm429@ (L.M.); rogierveltrop@ (R.V.); nci25@ (N.I.); julio.martin-garcia@ (J.M.-G.) 2 Pharmacology and Physiology Graduate Program, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA 3 Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA * Author to whom correspondence should be addressed; E-Mail: sonia.navas-martin@; Tel.: +1-15-762-7284, Fax: +1-215-762-8284. Received: 15 March 2012; in revised form: 12 May 2012 / Accepted: 23 May 2012 / Published: 24 May 2012 Abstract: Toll-like Receptors (TLRs) sense viral infections and induce production of type I interferons (IFNs), other cytokines, and chemokines. Viral recognition by TLRs and other pattern recognition receptors (PRRs) has been proven to be cell-type specific. Triggering of TLRs with selected ligands can be beneficial against some viral infections.