protein c a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)蛋白质c潜在生物标志物在严重脓毒症和可能的工具来监控治疗drotrecogin阿尔法(激活).pdfVIP
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protein c a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)蛋白质c潜在生物标志物在严重脓毒症和可能的工具来监控治疗drotrecogin阿尔法(激活)
Available online /content/12/2/R45
Vol 12 No 2 Open Access
Research
Protein C: a potential biomarker in severe sepsis and a possible
tool for monitoring treatment with drotrecogin alfa (activated)
1 2 3 4 4
Andrew F Shorr , David R Nelson , Duncan LA Wyncoll , Konrad Reinhart , Frank Brunkhorst ,
George Matthew Vail2 and Jonathan Janes2
1Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Irving Street, Washington, District of
Columbia 20010, USA
2Lilly Research Laboratories, Eli Lilly and Company, 520 S. Meridian, Indianapolis, Indiana 46285, USA
3Department of Critical Care, Guys and St Thomas NHS Foundation Trust, Lambeth Palace Road, London SE1 7EH, UK
4Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee, Jena 07740, Germany
Corresponding author: Andrew F Shorr, afshorr@
Received: 19 Nov 2007 Revisions requested: 9 Jan 2008 Revisions received: 13 Feb 2008 Published: 4 Apr 2008
Critical Care 2008, 12:R45 (doi:10.1186/cc6854)
This article is online at: /content/12/2/R45
© 2008 Shorr et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Drotrecogin alfa (activated; DrotAA) treatment, a Results Protein C was the only variable that correlated with
96-hour infusion, reduces 28-day mortality in severe sepsis to
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