protein quadratic indices of the “macromolecular pseudograph’s α-carbon atom adjacency matrix”. 1. prediction of arc repressor alanine-mutant’s stability蛋白质的二次指数u201c大分子伪书α-carbon原子邻接矩阵u201d。.pdfVIP
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protein quadratic indices of the “macromolecular pseudograph’s α-carbon atom adjacency matrix”. 1. prediction of arc repressor alanine-mutant’s stability蛋白质的二次指数u201c大分子伪书α-carbon原子邻接矩阵u201d。
Molecules 2004, 9, 1124–1147
molecules
ISSN 1420-3049
Protein Quadratic Indices of the “Macromolecular
Pseudograph’s α-Carbon Atom Adjacency Matrix”. 1.
Prediction of Arc Repressor Alanine-mutant’s Stability
Yovani Marrero Ponce 1,2*, Ricardo Medina Marrero 3, Eduardo A. Castro 4, Ronal Ramos de
Armas 2, Humberto González Díaz 2, Vicente Romero Zaldivar 5 and Francisco Torrens 6
1 Department of Pharmacy, Faculty of Chemical-Pharmacy, Central University of Las Villas, Santa
Clara, 54830, Villa Clara, Cuba.
2 Department of Drug Design, Chemical Bioactive Center, Central University of Las Villas, Santa
Clara, 54830, Villa Clara, Cuba.
3 Department of Microbiology, Chemical Bioactive Center, Central University of Las Villas, Santa
Clara, 54830, Villa Clara, Cuba.
4 INIFTA, División Química Teórica, Suc.4, C.C. 16, La Plata 1900, Buenos Aires, Argentina.
5 Faculty of Informatics, University of Cienfuegos, Cienfuegos, Cuba.
6 Institut Universitari de Ciència Molecular, Universitat de València, Dr. Moliner 50, E-46100
Burjassot (València), Spain.
* Author to whom correspondence should be addressed. Fax: (+53)-42-281130/281455; Telephone:
(+53)-42-281192/281473; E-mail: yovanimp@.cu or ymarrero77@yahoo.es
Received: 2 June 2004; in revised form 12 December 2004 / Accepted: 13 December 2004 /
Published: 31 December 2004
Abstract: This report describes a new set of macromolecular descriptors of relevance to
protein QSAR/QSPR studies, protein’s quadratic indices. These descriptors are calculated
from the macromolecular pseudograph’s α-carbon atom adjacency matrix. A study of the
protein stability effects for a complete set of ala
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