protein quadratic indices of the “macromolecular pseudograph’s α-carbon atom adjacency matrix”. 1. prediction of arc repressor alanine-mutant’s stability蛋白质的二次指数u201c大分子伪书α-carbon原子邻接矩阵u201d。.pdfVIP

protein quadratic indices of the “macromolecular pseudograph’s α-carbon atom adjacency matrix”. 1. prediction of arc repressor alanine-mutant’s stability蛋白质的二次指数u201c大分子伪书α-carbon原子邻接矩阵u201d。.pdf

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protein quadratic indices of the “macromolecular pseudograph’s α-carbon atom adjacency matrix”. 1. prediction of arc repressor alanine-mutant’s stability蛋白质的二次指数u201c大分子伪书α-carbon原子邻接矩阵u201d。

Molecules 2004, 9, 1124–1147 molecules ISSN 1420-3049 Protein Quadratic Indices of the “Macromolecular Pseudograph’s α-Carbon Atom Adjacency Matrix”. 1. Prediction of Arc Repressor Alanine-mutant’s Stability Yovani Marrero Ponce 1,2*, Ricardo Medina Marrero 3, Eduardo A. Castro 4, Ronal Ramos de Armas 2, Humberto González Díaz 2, Vicente Romero Zaldivar 5 and Francisco Torrens 6 1 Department of Pharmacy, Faculty of Chemical-Pharmacy, Central University of Las Villas, Santa Clara, 54830, Villa Clara, Cuba. 2 Department of Drug Design, Chemical Bioactive Center, Central University of Las Villas, Santa Clara, 54830, Villa Clara, Cuba. 3 Department of Microbiology, Chemical Bioactive Center, Central University of Las Villas, Santa Clara, 54830, Villa Clara, Cuba. 4 INIFTA, División Química Teórica, Suc.4, C.C. 16, La Plata 1900, Buenos Aires, Argentina. 5 Faculty of Informatics, University of Cienfuegos, Cienfuegos, Cuba. 6 Institut Universitari de Ciència Molecular, Universitat de València, Dr. Moliner 50, E-46100 Burjassot (València), Spain. * Author to whom correspondence should be addressed. Fax: (+53)-42-281130/281455; Telephone: (+53)-42-281192/281473; E-mail: yovanimp@.cu or ymarrero77@yahoo.es Received: 2 June 2004; in revised form 12 December 2004 / Accepted: 13 December 2004 / Published: 31 December 2004 Abstract: This report describes a new set of macromolecular descriptors of relevance to protein QSAR/QSPR studies, protein’s quadratic indices. These descriptors are calculated from the macromolecular pseudograph’s α-carbon atom adjacency matrix. A study of the protein stability effects for a complete set of ala

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