primary submucosal nodular plasmacytoma of thestomach a poorly recognized variant of gastriclymphoma胃里的主要黏膜下结节性浆细胞瘤gastriclymphoma公认的变异体.pdfVIP

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primary submucosal nodular plasmacytoma of thestomach a poorly recognized variant of gastriclymphoma胃里的主要黏膜下结节性浆细胞瘤gastriclymphoma公认的变异体.pdf

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primary submucosal nodular plasmacytoma of thestomach a poorly recognized variant of gastriclymphoma胃里的主要黏膜下结节性浆细胞瘤gastriclymphoma公认的变异体

Kanzawa et al. Diagnostic Pathology 2013, 8:30 /content/8/1/30 CASE REPORT Open Access Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma 1* 1 2 1 1 3 Maki Kanzawa , Chihoko Hirai , Yukiko Morinaga , Fumi Kawakami , Shigeo Hara , Hiroshi Matsuoka and Tomoo Itoh1 Abstract: Gastric plasmacytoma (GP) is a rare variant of gastric lymphomas. In the exceptional event that a patient presents with GP, the lesion occupies the mucosal layer in the vast majority of cases. Here we report a case of nodular plasmacytoma confined to the submucosa with no evidence of Helicobacter pylori (Hp) infection. The patient was a 59-year old female presenting with no particular symptoms. The tumor was well-demarcated and consisted of a diffuse monomorphic proliferation of plasma cells with numerous lymphoid follicles scattered throughout the tumor. The mucosal surface was intact and not associated with any tumor nodules. The cells were diffusely positive for CD79a, Bob1, EMA and IgA and consistently negative for CD3, CD19, CD20, PAX5, CD56, IgM and IgG. Additionally, in situ hybridization demonstrated clonality in the form of λ light-chain restriction. This submucosal nodular proliferation pattern of plasmacytoma is poorly recognized and considered to be a novel variant of lymphoma. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/3489998708673079 Keywords: Plasmacytoma, Solitary, Stomach, Submucosa, Lymphoma Background On the opposite end of the spectrum, extraosseous Extranodal marginal zone lymphomas