protective effects of the key compounds isolated from corni fructus against β-amyloid-induced neurotoxicity in pc12 cells保护作用的关键化合物分离出山茱萸果实对β-amyloid-induced在pc12细胞神经毒性.pdfVIP

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protective effects of the key compounds isolated from corni fructus against β-amyloid-induced neurotoxicity in pc12 cells保护作用的关键化合物分离出山茱萸果实对β-amyloid-induced在pc12细胞神经毒性.pdf

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protective effects of the key compounds isolated from corni fructus against β-amyloid-induced neurotoxicity in pc12 cells保护作用的关键化合物分离出山茱萸果实对β-amyloid-induced在pc12细胞神经毒性

Molecules 2012, 17, 10831-10845; doi:10.3390/molecules170910831 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells Seung-Young Hong 1,†, Woo-Sik Jeong 2,† and Mira Jun 1,* 1 Department of Food Science and Nutrition, Dong-A University, Busan 604-714, Korea; E-Mail: aseung02@ 2 Department of Food Life Sciences, Inje University, Gimhae, Gyeongnam 621-749, Korea; E-Mail: jeongws@inje.ac.kr † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: mjun@dau.ac.kr; Tel.: +82-51-200-7323; Fax: +82-51-200-7535. Received: 16 July 2012; in revised form: 1 September 2012 / Accepted: 5 September 2012 / Published: 10 September 2012 Abstract: β-Amyloid (Aβ) peptide is the major component of senile plaques and is considered to have a causal role in the development and progression of Alzheimer’s disease (AD). There is compelling evidence supporting the notion that Aβ-induced cytotoxicity is mediated though the generation of ROS. In the present study, we investigated the neuroprotective effects of ursolic acid (UA), p -coumaric acid (p -CA), and gallic acid (GA) isolated from Corni fructus (CF) against Aβ(25–35)-induced toxicity in PC12 cell. Exposure of PC12 cells to 50 μM Aβ(25–35) increased cellular oxidative stress, the number of apoptotic cells and caspase-3 activ