protective effects of celery juice in treatments with doxorubicin芹菜汁的保护作用与阿霉素治疗.pdfVIP

Molecules 2009, 14, 1627-1638; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effects of Celery Juice in Treatments with Doxorubicin Jovanka Kolarovic 1, Mira Popovic 2,*, Momir Mikov 3, Radoslav Mitic 4 and Ljiljana Gvozdenovic 5 1 Institute for Child and Youth Health Care of Vojvodina, Department of Hematology/Oncology, Novi Sad, Republic of Serbia 2 Department of Chemistry, Faculty of Science, University of Novi Sad, 21000 Novi Sad, Republic of Serbia, E-mail: popovic@ih.ns.ac.yu 3 Medical Faculty and Department of Pharmacology and Toxicology, University of Novi Sad, Republic of Serbia 4 Institute of Pharmacology, Faculty of Medicine, University of Pristina (Kosovska Mitrovica), Republic of Serbia 5 Department of Surgery, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Republic of Serbia * Author to whom correspondence should be addressed; E-mail: popovic@ih.ns.ac.yu; Tel.: +38 121 485 2770, Fax: +38 121 454 065. Received: 3 March 2009; in revised form: 14 April 2009/ Accepted: 23 April 2009 / Published: 24 April 2009 Abstract: The aim of this work was to investigate possible protective effect of celery juice in doxorubicin treatment. The following biochemical parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity in liver homogenate and blood hemolysate. We examined influence of