primary central nervous system plasmablastic lymphoma presenting in human immunodeficiency virus-negative but epstein-barr virus-positive patient a case report原发性中枢神经系统plasmablastic淋巴瘤呈现在人类免疫缺陷virus-negative但巴尔病毒呈阳性的病人身上一个病例报告.pdfVIP

Zhang et al. Diagnostic Pathology 2012, 7:51 /7/1/51 CASE REPORT Open Access Primary central nervous system plasmablastic lymphoma presenting in human immunodeficiency virus-negative but Epstein-Barr virus-positive patient: A case report 1 1 1* 1 1 2 3 Li Ying Zhang , Hui Yun Lin , Lan Xiang Gao , Lin Li , Yu Wang Tian , Zhi Qin Liu , Xiao Hua Shi and Zhi Yong Liang3 Abstract: We report a 32-year-old Outer Mongolian man, with plasmablastic lymphoma (PBL) primarily occured in the central nervous system and diagnosed by surgical resection. This patient appeared headache and Magnetic resonance imaging (MRI) showed multiple lesions in the right cerebral hemisphere including the right frontal- parietal lobe and right basal ganglia and the left cerebellum, he was diagnosed as lymphoma by stereotactic biopsy in January 2009 in local hospital, and was given radiotherapy 33 times after the biopsy. The patient was admitted to The Military General Hospital of Beijing PLA., Beijing, P.R. China on March 9th, 2011, with chief complaints of right limbs convulsioned suddenly, then fell down and lose of his consciousness, then awoke after 4 to 5 minutes, with symptoms of angulus oris numbness and the right upper limb powerless ten days ago. MRI of the brain revealed a well-defined hyperdense and enhancing mass in the left frontal-parietal lobe, the meninges are closely related, there was extensive peritumoural edema noted with pressure effects, as evident by effacement of the left lateral ventricles and a 0.5 cm shift of the midline to the right side. Surgical resection showed markedly atypical, large singly dispersed or cohesive proliferation of plasmacytoid cells with frequent abnormal mitoses and binucleatio