protective effect of polyphenols extract of adlay (coix lachryma-jobi l. var. ma-yuen stapf) on hypercholesterolemia-induced oxidative stress in rats保护作用的多酚提取adlay(薏苡属lachryma-jobi l . var. ma-yuen stapf)在大鼠hypercholesterolemia-induced氧化应激.pdfVIP

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protective effect of polyphenols extract of adlay (coix lachryma-jobi l. var. ma-yuen stapf) on hypercholesterolemia-induced oxidative stress in rats保护作用的多酚提取adlay(薏苡属lachryma-jobi l . var. ma-yuen stapf)在大鼠hypercholesterolemia-induced氧化应激.pdf

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protective effect of polyphenols extract of adlay (coix lachryma-jobi l. var. ma-yuen stapf) on hypercholesterolemia-induced oxidative stress in rats保护作用的多酚提取adlay(薏苡属lachryma-jobi l . var. ma-yuen stapf)在大鼠hypercholesterolemia-induced氧化应激

Molecules 2012, 17, 8886-8897; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats Lifeng Wang 1,2, Jing Sun 3, Qida Yi 2, Xuefeng Wang 2 and Xingrong Ju 1,2,* 1 School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 24122, China; E-Mail: wanglifeng_8@163.com 2 School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, Jiangsu 210046, China; E-Mails: yi.qida@ (Q.Y.); wangxuefeng2870@126.com (X.W.) 3 Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; E-Mail: sjing324@ * Author to whom correspondence should be addressed; E-Mail: xingrongju@163.com; Tel./Fax: +86-25-8402-8788. Received: 11 June 2012; in revised form: 15 July 2012 / Accepted: 21 July 2012 / Published: 26 July 2012 Abstract: The present study examines the effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) (APE) on high cholesterol diet fed rats (HCD). APE was orally administrated by gavage at doses of 10, 40 and 200 mg total phenolics/kg body weight of rats once a day for 28 days. At the end of four weeks, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), and markers of oxidative