protective effect of extract of cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats保护作用的冬虫夏草提取大脑中动脉occlusion-induced局灶性脑缺血大鼠.pdfVIP

Liu et al. Behavioral and Brain Functions 2010, 6:61 /content/6/1/61 RESEARCH Open Access Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats 1 1 1 1 2* Zhenquan Liu , Pengtao Li , Dan Zhao , Huiling Tang , Jianyou Guo Abstract Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of “self-medication” or “preventive medicine,” Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper. Methods: The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+ + K ATPase activity and glutathione S transferase activity in a rat model were studied respectively. Results: Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury. Conclusions: These experimental results suggest that complement Cordyceps sinensis extract is protective after cere