原创力文档prevention, screening and treatment of colorectal cancer a global and regional generalized cost effectiveness analysis预防、筛查和治疗结直肠癌的全球和区域广义成本效益分析.pdfVIP
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prevention, screening and treatment of colorectal cancer a global and regional generalized cost effectiveness analysis预防、筛查和治疗结直肠癌的全球和区域广义成本效益分析
Ginsberg et al. Cost Effectiveness and Resource Allocation 2010, 8:2
/content/8/1/2
RESEARCH Open Access
Prevention, screening and treatment of colorectal
cancer: a global and regional generalized cost
effectiveness analysis
1* 1 1 1 2
Gary M Ginsberg , Stephen S Lim , Jeremy A Lauer , Benjamin P Johns , Cecilia R Sepulveda
Abstract
Background: Regional generalized cost-effectiveness estimates of prevention, screening and treatment
interventions for colorectal cancer are presented.
Methods: Standardised WHO-CHOICE methodology was used. A colorectal cancer model was employed to
provide estimates of screening and treatment effectiveness. Intervention effectiveness was determined via a
population state-transition model (PopMod) that simulates the evolution of a sub-regional population accounting
for births, deaths and disease epidemiology. Economic costs of procedures and treatment were estimated,
including programme overhead and training costs.
Results: In regions characterised by high income, low mortality and high existing treatment coverage, the addition
of screening to the current high treatment levels is very cost-effective, although no particular intervention stands
out in cost-effectiveness terms relative to the others.
In regions characterised by low income, low mortality with existing treatment coverage around 50%, expanding
treatment with or without screening is cost-effective or very cost-effective. Abandoning treatment in favour of
screening (no treatment scenario) would not be cost effective.
In regions characterised by low income, high mortality and low treatment levels, the most cost-effective interven-
tion is expanding treatment.
Conclusions: From a cost-effectiveness standpo
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