原创力文档prostatic response to supranutritional selenium supplementation comparison of the target tissue potency of selenomethionine vs. selenium-yeast on markers of prostatic homeostasis前列腺应对supranutritional硒补充硒代蛋氨酸的目标组织效能的比较与硒酵母在前列腺内稳态的标志.pdfVIP
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prostatic response to supranutritional selenium supplementation comparison of the target tissue potency of selenomethionine vs. selenium-yeast on markers of prostatic homeostasis前列腺应对supranutritional硒补充硒代蛋氨酸的目标组织效能的比较与硒酵母在前列腺内稳态的标志
Nutrients 2012, 4, 1650-1663; doi:10.3390/nu4111650
OPEN ACCESS
nutrients
ISSN 2072-6643
/journal/nutrients
Art icle
Prostatic Response to Supranutritional Selenium
Supplementation: Comparison of the Target Tissue Potency
of Selenomethionine vs. Selenium-Yeast on Markers of
Prostatic Homeostasis
David J. Waters 1,2,3,*, Shuren Shen 3, Seema S. Kengeri 3, Emily C. Chiang 3,
Gerald F. Combs, Jr. 4, J. Steven Morris 5,6 and David G. Bostwick 7
1 Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907, USA
2 The Center on Aging and the Life Course, Purdue University, West Lafayette, IN 47907, USA
3 Gerald P. Murphy Cancer Foundation, West Lafayette, IN 47906, USA;
E-Mails: seleniumhealth@ (S.S.); seema@ (S.S.K.);
chiang1@ (E.C.C.)
4 USDA-ARS Grand Forks Human Nutrition Research Center, Grand Forks, ND 58203, USA;
E-Mail: bs@
5 University of Missouri-Columbia Research Reactor Center, Columbia, MO 65211, USA;
E-Mail: morrisj@
6 Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA
7 Bostwick Laboratories, Glen Allen, VA 23060, USA;
E-Mail: dbostwick@
* Author to whom correspondence should be addressed; E-Mail: waters@;
Tel.: + 1-765-775-1005; Fax: + 1-765-775-1006.
Received: 13 September 2012; in revised form: 26 October 2012 / Accepted: 26 October 2012 /
Published: 6 November 2012
Abstract: Prostate cancer is the product of dysregulated homeostasis within the aging
prostate. Supplementation with selenium in the form of selenized yeast (Se-yeast)
significantly reduced prostate
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