prostaglandin e2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability前列腺素e2类型2-selective受体激动剂可以防止关节软骨的退化在兔膝关节创伤性不稳定.pdfVIP

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prostaglandin e2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability前列腺素e2类型2-selective受体激动剂可以防止关节软骨的退化在兔膝关节创伤性不稳定.pdf

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prostaglandin e2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability前列腺素e2类型2-selective受体激动剂可以防止关节软骨的退化在兔膝关节创伤性不稳定

Mitsui et al. Arthritis Research Therapy 2011, 13:R146 /content/13/5/R146 RESEARCH ARTICLE Open Access Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability 1,3 1,4* 1,2 1,3 1 5 Hiroto Mitsui , Tomoki Aoyama , Moritoshi Furu , Kinya Ito , Yonghui Jin , Takayuki Maruyama , 5 5 5 5 3 2 Toshiya Kanaji , Shinsei Fujimura , Hikaru Sugihara , Akio Nishiura , Takanobu Otsuka , Takashi Nakamura and Junya Toguchida 1,2,6 Abstract Introduction: Osteoarthritis (OA) is a common cause of disability in older adults. We have previously reported that an agonist for subtypes EP2 of the prostaglandin E2 receptor (an EP2 agonist) promotes the regeneration of chondral and osteochondral defects. The purpose of the current study is to analyze the effect of this agonist on articular cartilage in a model of traumatic degeneration. Methods: The model of traumatic degeneration was established through transection of the anterior cruciate ligament and partial resection of the medial meniscus of the rabbits. Rabbits were divided into 5 groups; G-S (sham operation), G-C (no further treatment), G-0, G-80, and G-400 (single intra-articular administration of gelatin hydrogel containing 0, 80, and 400 μg of the specific EP2 agonist, ONO-8815Ly, respectively). Degeneration of the articular cartilage was evaluated at 2 or 12 weeks after the operation. Results: ONO-8815Ly prevented cartilage degeneration at 2 weeks, which was associated with the inhibition of matrix metalloproteinase-13 (MMP-13) ex