原创力文档quantitative assessment of brown adipose tissue metabolic activity and volume using 18f-fdg petct and β3-adrenergic receptor activation褐色脂肪组织的代谢活动的定量评估和体积使用18 f-fdg petctβ3-adrenergic受体激活.pdfVIP
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quantitative assessment of brown adipose tissue metabolic activity and volume using 18f-fdg petct and β3-adrenergic receptor activation褐色脂肪组织的代谢活动的定量评估和体积使用18 f-fdg petctβ3-adrenergic受体激活
Mirbolooki et al. EJNMMI Research 2011, 1:30
/content/1/1/30
ORIGINAL RESEARCH Open Access
Quantitative assessment of brown adipose tissue
metabolic activity and volume using 18F-FDG
PET/CT and β3-adrenergic receptor activation
*
M Reza Mirbolooki, Cristian C Constantinescu, Min-Liang Pan and Jogeshwar Mukherjee
Abstract
Background: Brown adipose tissue [BAT] metabolism in vivo is vital for the development of novel strategies in
combating obesity and diabetes. Currently, BAT is activated at low temperatures and measured using 2-deoxy-2-
18F-fluoro-D-glucose [18F-FDG] positron-emission tomography [PET]. We report the use of b3-adrenergic receptor-
mediated activation of BAT at ambient temperatures using (R, R)-5-[2-[2,3-(3-chlorphenyl)-2-hydroxyethyl-amino]
propyl]-1,3-benzodioxole-2,2-dicarboxylate, disodium salt [CL316,243] (a selective b3-adrenoceptor agonist) and
measured by 18F-FDG PET/computed tomography [CT].
Methods: Control and CL316,243-treated (2 mg/kg) male Sprague-Dawley rats were administered with 18F-FDG for
PET/CT studies and were compared to animals at cold temperatures. Receptor-blocking experiments were carried
out using propranolol (5 mg/kg). Dose effects of CL316,243 were studied by injecting 0.1 to 1 mg/kg 30 min prior
to 18F-FDG administration. Imaging results were confirmed by autoradiography, and histology was done to confirm
BAT activation.
Results: CL316,243-activated interscapular BAT [IBAT], cervical, periaortic, and intercostal BATs were clearly
visualized by PET. 18F-FDG uptake of IBAT was increased 12-fold by CL316,243 vs. 1.1-fold by cold exposure when
compared to controls. 18F-FDG uptake of the CL-activated IBAT was reduced by 96.0% using intraperitoneal
administration of
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