quantitative determination of fibrinogen of patients with coronary heart diseases through piezoelectric agglutination sensor定量测定纤维蛋白原的冠状动脉心脏疾病患者通过压电传感器凝集.pdfVIP

Sensors 2010, 10, 2107-2118; doi:10.3390/s100302017 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Quantitative Determination of Fibrinogen of Patients with Coronary Heart Diseases through Piezoelectric Agglutination Sensor Qinghai Chen 1,*, Xing Hua 1, Weiling Fu 1,*, Dongbo Liu 1, Ming Chen 1 and Guoru Cai 2 1 Laboratory, The Clinical Experimental Base of Biosensor and Microarray, The Center of Molecule and Gene Diagnosis, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; E-Mails: huaxing525@ (X.H); Liudong_bo@ (D.L.); chengming1971@ (M.C.) 2 The 26th Electronics Research Institute, National Information Industry Department, Chongqing 400060, China; E-Mail: guorucai1954@ (G.C.) * Author to whom correspondence should be addressed; E-Mails: fuweinin@ (W.F.); cqh1969@ (Q.C.); Tel.: +86-23 Fax: +86-23 Received: 8 January 2010; in revised form: 8 February 2010 / Accepted: 1 March 2010 / Published: 16 March 2010 Abstract: Fibrinogen can transform fibrin through an agglutination reaction, finally forming fibrin polymer with grid structure. The density and viscosity of the reaction system changes drastically during the course of agglutination. In this research, we apply an independently-developed piezoelectric agglutination sensor to detect the fibrinogen agglutination reaction in patients with coronary heart diseases. The terminal judgment method of determining plasma agglutination reaction