quantitative genetics of taura syndrome resistance in pacific white shrimp (penaeus vannamei) a cure model approach数量遗传学taura综合症的阻力在太平洋白虾(中国对虾)治疗模型的方法.pdfVIP

Ødegård et al. Genetics Selection Evolution 2011, 43:14 Ge n e t i c s /content/43/1/14 Se l e c t i o n Evolution RESEARCH Open Access Quantitative genetics of taura syndrome resistance in pacific white shrimp (penaeus vannamei): a cure model approach 1,2* 3,4 5 2 3 1,2 Jørgen Ødegård , Thomas Gitterle , Per Madsen , Theo HE Meuwissen , M Hossein Yazdi , Bjarne Gjerde , Carlos Pulgarin4 and Morten Rye3 Abstract Background: In aquaculture breeding, resistance against infectious diseases is commonly assessed as time until death under exposure to a pathogen. For some diseases, a fraction of the individuals may appear as “cured” (non-susceptible), and the resulting survival time may thus be a result of two confounded underlying traits, i.e., endurance (individual hazard) and susceptibility (whether at risk or not), which may be accounted for by fitting a cure survival model. We applied a cure model to survival data of Pacific white shrimp (Penaeus vannamei) challenged with the Taura syndrome virus, which is one of the major pathogens of Panaeid shrimp species. Methods: In total, 15,261 individuals of 513 full-sib families from three generations were challenge-tested in 21 separate tests (tanks). All challenge-tests were run until mortality naturally ceased. Time-until-event data were analyzed with a mixed cure survival model using Gibbs sampling, treating susceptibility and enduran