quantitative imaging assessment of blood-brain barrier permeability in humans定量成像评估血脑屏障通透性的人类.pdfVIP

Chassidim et al. Fluids and Barriers of the CNS 2013, 10:9 FLUIDS AND BARRIERS /content/10/1/9 OF THE CNS REVIEW Open Access Quantitative imaging assessment of blood-brain barrier permeability in humans Yoash Chassidim1,2*, Ronel Veksler1,2, Svetlana Lublinsky1,2, Gaby S Pell3,4, Alon Friedman1 and Ilan Shelef2 Abstract The blood–brain barrier (BBB) is a functional and structural barrier separating the intravascular and neuropil compartments of the brain. It characterizes the vascular bed and is essential for normal brain functions. Dysfunction in the BBB properties have been described in most common neurological disorders, such as stroke, traumatic injuries, intracerebral hemorrhage, tumors, epilepsy and neurodegenerative disorders. It is now obvious that the BBB plays an important role in normal brain activity, stressing the need for applicable imaging and assessment methods. Recent advancements in imaging techniques now make it possible to establish sensitive and quantitative methods for the assessment of BBB permeability. However, most of the existing techniques require complicated and demanding dynamic scanning protocols that are impractical and cannot be fulfilled in some cases. We review existing methods for the evaluation of BBB permeability, focusing on quantitative magnetic resonance-based approaches and discuss their drawbacks and limitations. In light of those limitations we propose two new approaches for BBB assessment with less demanding imaging sequences: the “post-pre” and the “linear dynamic” methods, both allow semi-quantitative permeability assessment and