quantitative pinch stimulator for exploring evoked nociceptive responses a pilot study定量压力刺激器为探索诱发疼痛的反应一个试点研究.pdfVIP

Chen et al. BioMedical Engineering OnLine 2010, 9:79 /content/9/1/79 RESEARCH Open Access Quantitative pinch stimulator for exploring evoked nociceptive responses: A pilot study 1 1 1 1 1 2 1* Chih-Ping Chen , Wen-Li Liao , Yi-Li Tseng , Pen-Li Lu , Yu-Chun Lo , You-Yin Chen , Fu-Shan Jaw * Correspondence: jaw@.tw Abstract 1Institute of Biomedical Engineering, College of Background: A mechanical noxious stimulator is useful for studies of pain, both for Engineering and College of Medicine, National Taiwan clinic and basic research. We propose to use a pinch stimulator that can not only University, Taipei, Taiwan generate a quantitative, reproducible noxious pinch but also simultaneously provide a synchronous external trigger signal, which is essential for acquisition of evoked potentials. Methods: For ethical considerations, audible and visual aids were incorporated so that pinch force could be regulated within a predetermined level. Reproducibility of the nociceptive responses evoked by this device was validated. The device was constructed with a simple circuit, and the element build-in was delicately selected for the minimum required to produce evoked potentials. Results: The magnitude of the force output is linearly proportional to the volts produced by the device (i.e., during the pinch). Increases in force correspond to