quantitative structure ？ antiprotozoal activity relationships of sesquiterpene lactones倍半萜烯内酯的定量结构 antiprotozoal活动关系.pdfVIP

Molecules 2009, 14, 2062-2076; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Quantitative Structure ‒ Antiprotozoal Activity Relationships of Sesquiterpene Lactones † Thomas J. Schmidt 1,*, Amal M. M. Nour 1, Sami A. Khalid 2, Marcel Kaiser 3 and Reto Brun 3 1 Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische Biologie und Phytochemie, Hittorfstraße 56, D-48149 Münster, Germany; E-mails: amal_mukhtar@ (A-M.N.) 2 University of Khartoum, Department of Pharmacognosy, Faculty of Pharmacy, P.O. box 1996, Khartoum, Sudan; E-mail: khalidseek@ (S.K.) 3 Swiss Tropical Institute (STI), Socinstrasse 57, CH-4002 Basel, Switzerland; E-mails: Marcel.Kaiser@unibas.ch (M.K.), Reto.Brun@unibas.ch (R.B.) † th This work is cordially dedicated to G. Willuhn, Düsseldorf, on the occasion of his 75 birthday * Author to whom correspondence should be addressed; E-mail: thomschm@uni-muenster.de Received: 12 May 2009; in revised form: 4 June 2009 / Accepted: 5 June 2009 / Published: 8 June 2009 Abstract: Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have now conducted a structure-(in-vitro)- activity study on a set of 40 STLs against T. br