quantitative trait loci mapping in dairy cattle review and meta-analysis映射在奶牛数量性状回顾和荟萃分析.pdfVIP

Genet. Sel. Evol. 36 (2004) 163–190 163 c INRA, EDP Sciences, 2004 DOI: 10.1051/gse:2003057 Original article Quantitative trait loci mapping in dairy cattle: review and meta-analysis ∗ Mehar S. K, Peter C. T , Imke T, Herman W. R Centre for Advanced Technologies in Animal Genetics and Reproduction (ReproGen), and Co-operative Research Centre for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney, PMB 3, Camden NSW 2570, Australia (Received 4 July 2003; accepted 29 October 2003) Abstract – From an extensive review of public domain information on dairy cattle quantitative trait loci (QTL), we have prepared a draft online QTL map for dairy production traits. Most pub- lications (45 out of 55 reviewed) reported QTL for the major milk production traits (milk, fat and protein yield, and fat and protein concentration (%)) and somatic cell score. Relatively few QTL studies have been reported for more complex traits such as mastitis, fertility and health. The collated QTL map shows some chromosomal regions with a high density of QTL, as well as a substantial number of QTL at single chromosomal locations. To extract the most informa- tion from these published records, a meta-analysis was conducted to obtain consensus on QTL location and allelic substitution effect of these QTL. This required modification and develop- ment of statistical methodologies. The meta-analysis indicated a number of consensus regions, the most striking being two distinct regions affecting milk yield on chromosome 6 at 49 cM and 87 cM explaining 4.2 and 3.6 percent of the genetic variance of milk yield, respectively. The first of