quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat定量步态分析作为方法来评估机械痛觉过敏调制adjuvant-induced关节炎疾病修饰antirheumatoid药物的老鼠.pdfVIP

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quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat定量步态分析作为方法来评估机械痛觉过敏调制adjuvant-induced关节炎疾病修饰antirheumatoid药物的老鼠.pdf

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quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat定量步态分析作为方法来评估机械痛觉过敏调制adjuvant-induced关节炎疾病修饰antirheumatoid药物的老鼠

Available online /content/9/5/R91 Vol 9 No 5 Open Access Research article Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat 1 1 2 2 Shabana Usman Simjee , Huma Jawed , Javeria Quadri and Sheikh Arshad Saeed 1HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan 2Dr Panjwani Centre for Molecular Medicine and Drug Research, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan Corresponding author: Shabana Usman Simjee, shabana.simjee@ Received: 23 May 2007 Revisions requested: 10 Aug 2007 Revisions received: 21 Aug 2007 Accepted: 11 Sep 2007 Published: 11 Sep 2007 Arthritis Research Therapy 2007, 9:R91 (doi:10.1186/ar2290) This article is online at: /content/9/5/R91 © 2007 Simjee et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract In the present study, azothioprine, chloroquine, D-penicillamine, the arthritic rats treated with azothioprine, chloroquine, sodium methotrexate and sodium aurothiomalate (gold salt) were aurothiomalate and methotrexate. D-Penicillamine (12.5 mg/kg/ evaluated for possible disease-modifying effects in the adjuvant- day), however, showed a significant reduction (P 0.03) in the induced arthritis model of hum