quantitative estimation of genetic risk for atypical scrapie in french sheep and potential consequences of the current breeding programme for resistance to scrapie on the risk of atypical scrapie定量估算遗传风险的非典型羊搔痒症的法语和潜在后果上当前抗痒病育种计划的典型痒病的风险.pdfVIP

Fediaevsky et al. Genetics Selection Evolution 2010, 42:14 Ge n e t i c s /content/42/1/14 Se l e c t i o n Evolution R E S E A R C H Open Access Research Quantitative estimation of genetic risk for atypical scrapie in French sheep and potential consequences of the current breeding programme for resistance to scrapie on the risk of atypical scrapie 1,2 2 1 3 3 Alexandre Fediaevsky* , Didier Calavas , Patrick Gasqui , Katayoun Moazami-Goudarzi , Pascal Laurent , Jean- 2 1 4 Noël Arsac , Christian Ducrot and Carole Moreno Abstract Background: Since 2002, active surveillance programmes have detected numerous atypical scrapie (AS) and classical scrapie cases (CS) in French sheep with almost all the PrP genotypes. The aim of this study was 1) to quantify the genetic risk of AS in French sheep and to compare it with the risk of CS, 2) to quantify the risk of AS associated with the increase of the ARR allele frequency as a result of the current genetic breeding programme against CS. Methods: We obtained genotypes at codons 136, 141, 154 and 171 of the PRNP gene for representative samples of 248 AS and 245 CS cases. We used a random sample of 3,317 scrapie negative animals genotyped at codons 136, 154 and 171 and we made inferences on the position 141 by multiple imputations, using external data. To estimate the risk associated with PrP genotypes, we fitted