quantitative evaluation of compliance with recommendation for sulfonylurea dose co-administered with dpp-4 inhibitors in japan定量评价遵守建议的剂量磺酰脲类流行性流感减毒活疫苗dpp-4抑制剂在日本.pdfVIP

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quantitative evaluation of compliance with recommendation for sulfonylurea dose co-administered with dpp-4 inhibitors in japan定量评价遵守建议的剂量磺酰脲类流行性流感减毒活疫苗dpp-4抑制剂在日本.pdf

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quantitative evaluation of compliance with recommendation for sulfonylurea dose co-administered with dpp-4 inhibitors in japan定量评价遵守建议的剂量磺酰脲类流行性流感减毒活疫苗dpp-4抑制剂在日本

Pharmaceutics 2012, 4, 479-493; doi:10.3390/pharmaceutics4030479 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Article Quantitative Evaluation of Compliance with Recommendation for Sulfonylurea Dose Co-Administered with DPP-4 Inhibitors in Japan Tomomi Kimura 1,2,*, Kazuhito Shiosakai 2,3, Yasuaki Takeda 4, Shinji Takahashi 5, 4 2 Masahiko Kobayashi and Motonobu Sakaguchi 1 Epidemiology, Janssen Pharmaceutical K.K., 2-5-3, Nishi-Kanda, Chiyoda-ku, Tokyo 101-0065, Japan 2 Pro-Bono Pharmacoepidemiologists Committee in Japan, Japan 3 Clinical Data and Biostatistics, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan 4 Sales planning group, Japan Medical Research Institute Co. Ltd. 9-1 Marunouchi 1-chome, Chiyoda-ku, Tokyo 100-6739, Japan 5 Nihon Chouzai Co. Ltd. 9-1 Marunouchi 1-chome, Chiyoda-ku, Tokyo 100-6737, Japan * Author to whom correspondence should be addressed; E-Mail: tkimura1@; Tel.: +81-3-4411-5958; Fax: +81-3-4411-5086. Received: 11 June 2012; in revised form: 8 August 2012 / Accepted: 30 August 2012 / Published: 19 September 2012 Abstract: After the launch of dipeptidyl peptidase-4 (DPP-4), a new oral hypoglycemic drug (OHD), in December 2009, severe hypoglycemia cases were reported in Japan. Although the definite cause was unknown, co-administration with sulfonylureas (SU) was suspected as one of the potential risk factors. The Japan Association for Diabetes Educ