prospective evaluation of indirect costs due to acute rotavirus gastroenteritis in spain the rotacost study前瞻性评估间接成本由于急性轮状病毒肠胃炎在西班牙rotacost研究.pdfVIP

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prospective evaluation of indirect costs due to acute rotavirus gastroenteritis in spain the rotacost study前瞻性评估间接成本由于急性轮状病毒肠胃炎在西班牙rotacost研究.pdf

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prospective evaluation of indirect costs due to acute rotavirus gastroenteritis in spain the rotacost study前瞻性评估间接成本由于急性轮状病毒肠胃炎在西班牙rotacost研究

Bouzón-Alejandro et al. BMC Pediatrics 2011, 11:81 /1471-2431/11/81 RESEARCH ARTICLE Open Access Prospective evaluation of indirect costs due to acute rotavirus gastroenteritis in Spain: the ROTACOST study Marta Bouzón-Alejandro1,3†, Lorenzo Redondo-Collazo1,2,3, Juan Manuel Sánchez-Lastres3,4, Nazareth Martinón-Torres1,2,3, José María Martinón-Sánchez1,2,3 and Federico Martinón-Torres1,2,3*†, for the ROTACOST research team5 Abstract Background: The effect of rotavirus in developed countries is mainly economic. This study aimed to assess the indirect costs induced by rotavirus acute gastroenteritis (RVAGE) in Spain. Methods: A prospective observational study was conducted from October 2008 to June 2009. It included 682 children up to 5 years of age with acute gastroenteritis (AGE) who attended primary care (n = 18) and emergency room/hospital settings (n = 10), covering the regions of Galicia and Asturias (North-west Spain). All non-medical expenses incurred throughout the episode were recorded in detail using personal interviews and telephone contact. Results: Among the 682 enrolled children, 207 (30.4%) were rotavirus positive and 170 (25%) had received at least one dose of rotavirus vaccine. The mean (standard deviation) indirect cost caused by an episode of AGE was estimated at 135.17 (182.70) Euros. Costs were 1.74-fold higher when AGE was caused by rotavirus compared with other etiologies: 192.7 (219.8) Euros vs. 111.6 (163.5) Euros (p .001). The costs for absenteeism were the most substantial with a mean of 91.41 (134.76) Euros per family, resulting in a loss of 2.45 (3.17) days of work. In RVAGE patients, the absenteeism cost was 120.4 (154) Euros compared with 75.8 (123) for the other etiologies (p = .002), because of loss of 3.5 (3.6) vs 1.9 (2.9) days of work (p .001). Meals costs were 2-fold-higher