prevention and treatment of recurrent hepatitis b after liver transplantation the current role of nucleoside and nucleotide analogues预防和治疗肝移植后乙型肝炎复发的当前角色的核苷和核苷酸类似物.pdfVIP

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prevention and treatment of recurrent hepatitis b after liver transplantation the current role of nucleoside and nucleotide analogues预防和治疗肝移植后乙型肝炎复发的当前角色的核苷和核苷酸类似物.pdf

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prevention and treatment of recurrent hepatitis b after liver transplantation the current role of nucleoside and nucleotide analogues预防和治疗肝移植后乙型肝炎复发的当前角色的核苷和核苷酸类似物

Annals of Clinical Microbiology and Antimicrobials BioMed Central Review Open Access Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues Ian R Schreibman and Eugene R Schiff* Address: From the Center for Liver Diseases, Division of Hepatology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA Email: Ian R Schreibman - IanRoyS@; Eugene R Schiff* - eschiff@ * Corresponding author Published: 06 April 2006 Received: 25 February 2006 Accepted: 06 April 2006 Annals of Clinical Microbiology and Antimicrobials2006, 5:8 doi:10.1186/1476-0711-5-8 This article is available from: /content/5/1/8 © 2006Schreibman and Schiff; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The Hepatitis B virus (HBV) is a DNA virus that can cause both acute and chronic liver disease in humans. Approximately 350–400 million people are affected worldwide and up to one million deaths occur annually from cirrhosis and hepatocellular carcinoma. When cirrhosis and liver failure develop, the definitive treatment of choice remains orthotopic liver transplantation (OLT). In the past, an unacceptable HBV recurrence rate with a high rate of graft los