predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, mwanza- tanzania阳性血培养和死亡的预测因子与疑似新生儿脓毒症新生儿三级医院,竭尽全力,坦桑尼亚.pdfVIP

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predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, mwanza- tanzania阳性血培养和死亡的预测因子与疑似新生儿脓毒症新生儿三级医院,竭尽全力,坦桑尼亚.pdf

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predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, mwanza- tanzania阳性血培养和死亡的预测因子与疑似新生儿脓毒症新生儿三级医院,竭尽全力,坦桑尼亚

Kayange et al. BMC Pediatrics 2010, 10:39 /1471-2431/10/39 R E S E A R C H A R T I C L E Open Access Research article Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza- Tanzania 1 2 1 3 3 Neema Kayange , Erasmus Kamugisha , Damas L Mwizamholya , Seni Jeremiah and Stephen E Mshana* Abstract Background: Neonatal sepsis is a significant cause of morbidity and mortality in neonates. Appropriate clinical diagnosis and empirical treatment in a given setting is crucial as pathogens of bacterial sepsis and antibiotic sensitivity pattern can considerably vary in different settings. This study was conducted at Bugando Medical Centre (BMC), Tanzania to determine the prevalence of neonatal sepsis, pred ictors of positive blood culture, deaths and antimicrobial susceptibility, thus providing essential information to formulate a policy for management of neonatal sepsis. Methods: This was a prospective cross sectional study involv ing 300 neonates admitted at BMC neonatal unit between March and November 2009. Standard data collection form was used to collect all demographic data and clinical characteristics of neonates. Blood culture was done on Brain Heart Infusion broth followed by identification of isolates using conventional methods and testing for their susceptibility to antimicrobial agents using the disc diffusion method. Results: Among 770 neonates admitted during the study period; 300 (38.9%) neonates were diagnosed to have neonatal sepsis by WHO criteria. Of 300 neonates with clinical neonatal sepsis 121(40%) and 179(60%) had early and late onset sepsis respectively. Positive blood culture was found in 57 (47.1%) and 92 (51.4%) among