recent progress in unraveling central nervous system processing of itch sensation最近的进展解开中枢神经系统处理瘙痒的感觉.pdfVIP

REVIEW ARTICLE Recent Progress in Unraveling Central Nervous System Processing of Itch Sensation Florian Pfab,*§ Michael Valet,þ Thomas To¨lle,þ Heidrun Behrendt,§ Johannes Ring,* and Ulf Darsow*§ EPPENDORF ITCH QUESTIONNAIRE Abstract: Itch is the major symptom of many allergic or inflamma- tory skin diseases, yet it is still difficult to measure objectively. This The quantity and quality of perceived itch show specific article shows and updates the development and approaches of central characteristics in different pruritic skin diseases. Clinical nervous system investigation of itch. observations point to differences in the central nervous Human neuroimaging studies on the physiology and pathophys- processing of pruritus. The multidimensional Eppendorf Itch iology of itch sensation have been hampered by the lack of a re- Questionnaire (EIQ)9 was used in hospitalized patients producible Bon-off[ stimulus. Short-term alternating temperature experiencing atopic eczema (AE, n = 62) or chronic urticaria modulation of histamine-induced itch has recently been shown to (n = 58). Total scores (127 items), emotional and sensory provide on-off characteristics. ratings, reactive behavior and visual analogue scale (VAS) Recent studies with functional magnetic resonance imaging ratings for itch intensity were evaluated. The mean VAS ratings demonstrate that itch sensation in healthy volunteers is processed by of itch intensity showed no significant difference b