recent n-atom containing compounds from indo-pacific invertebrates最近n-atom包含化合物从印支无脊椎动物.pdfVIP

Mar. Drugs 2010, 8, 2810-2836; doi:10.3390/md8112810 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review Recent N-Atom Containing Compounds from Indo-Pacific Invertebrates Yoel Kashman 1,*, Ashgan Bishara 1 and Maurice Aknin 2 1 School of Chemistry, Tel Aviv University, Tel Aviv University, Ramat Aviv 69978, Israel 2 Laboratorie de Chimîe des Substances Naturelles et des Aliments, Faculté des Sciences et Techniques, Université de Réunion, 15 Avenue Rene Cassin, B.P. 7151, 97715 Saint Denis, Cedex 9, France * Author to whom correspondence should be addressed; E-Mail: kashman@post.tau.ac.il; Tel.: +972 Fax: +972-3-6409293. Received: 19 September 2010; in revised form: 3 November 2010 / Accepted: 8 November 2010 / Published: 10 November 2010 Abstract: A large variety of unique N-atom containing compounds (alkaloids) without terrestrial counterparts, have been isolated from marine invertebrates, mainly sponges and ascidians. Many of these compounds display interesting biological activities. In this report we present studies on nitrogenous compounds, isolated by our group during the last few years, from Indo-Pacific sponges, one ascidian and one gorgonian. The major part of the review deals with metabolites from the Madagascar sponge Fascaplysinopsis sp., namely, four groups of secondary metabolites, the salarins, tulearins, taumycins and tausalarins. Keywords: heterocycles; Fascaplysinopsis sp.; marine invertebrates; nitrogenous macrolide; leukemia cells 1. Introduction