recent key advances in human immunodeficiency virus medicine and implications for china最近主要的进步人类免疫缺陷病毒药品和对中国的影响.pdfVIP

Sun et al. AIDS Research and Therapy 2010, 7:12 /content/7/1/12 R E V I E W Open Access Review Recent key advances in human immunodeficiency virus medicine and implications for China 1,2 3 4 1 3,5 Kai Sun , Shuntai Zhou , Ray Y Chen , Myron S Cohen* and Fujie Zhang* Abstract In this article we summarize several recent major developments in human immunodeficiency virus treatment, prevention, outcome, and social policy change. Updated international guidelines endorse more aggressive treatment strategies and safer antiretroviral drugs. New antiretroviral options are being tested. Important lessons were learned in the areas of human immunodeficiency virus vaccines and microbicide gels from clinical studies, and additional trials in prevention, especially pre-exposure prophylaxis, are nearing completion. Insight into the role of the virus in the pathogenesis of diseases traditionally thought to be unrelated to acquired immunodeficiency syndrome has become a driving force for earlier and universal therapy. Lastly, we review important achievements of and future challenges facing China as she steps into her eighth year of the National Free Antiretroviral Treatment Program. Introduction HIV Treatment Antiretroviral therapy (ART) has evolved from mono- New Strategies therapy with zidovudine (AZT) to the use of combination The US Department of Health and Human Services nucleoside reverse transcriptase inhibitors (NRTIs), to (DHHS) [4] and the World Health Organization (WHO) triple therapy with highly active antiretroviral therapy [5] both released