relationship between inflammatory cytokines and uric acid levels with adverse cardiovascular outcomes in patients with stable coronary heart disease炎性细胞因子之间的关系和尿酸水平与冠心病患者不良心血管结果稳定.pdfVIP

Relationship between Inflammatory Cytokines and Uric Acid Levels with Adverse Cardiovascular Outcomes in Patients with Stable Coronary Heart Disease 1 1 2 3 4 Dietrich Rothenbacher *, Andrea Kleiner , Wolfgang Koenig , Paola Primatesta , Lutz P. Breitling , Hermann Brenner4 1 Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany, 2 Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany, 3 Global Clinical Epidemiology, Novartis Pharma AG, Basel, Switzerland, 4 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany Abstract Background: So far it is unclear whether the association between serum uric acid (SUA), inflammatory cytokines and risk of atherosclerosis is causal or an epiphenomenon. The aim of the project is to investigate the independent prognostic relationship of inflammatory markers and SUA levels with adverse cardiovascular outcomes in a patient population with stable coronary heart disease (CHD). Methods: SUA, C-reactive protein (CRP) and interleukin (IL)-6 were measured at baseline in a cohort of 1,056 patients aged 30–70 years with CHD. Cox proportional hazards model was used to determine the prognostic value of these markers on a combined CVD endpoint during eight year follow-up after adjustment for covariates. Results: For 1,056 patients with stable coronary heart disease aged 30–70 years (mean age 58.9 years, SD 8.0) follow-up information and serum measurements were complete and n = 151 patients (incidence 21.1 per 1000 patients years) experienced a fatal or non-fatal CVD event during follow-up (p-value = 0.05 for quartiles of SUA, p = 0.002 for