recruitment of dendritic cells and macrophages during t cell-mediated synovial inflammation招聘的树突细胞和巨噬细胞在t细胞介导的滑膜炎症.pdfVIP

Available online /content/9/6/R120 Vol 9 No 6 Open Access Research article Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation 1 1,2 3 1,3 Mahin Moghaddami , Leslie G Cleland , Gorjana Radisic and Graham Mayrhofer 1Arthritis Research Laboratory, Hanson Research Institute, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia, 5000, Australia 2Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, 5000, Australia 3Discipline of Microbiology and Immunology, School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide, South Australia, 5005, Australia Corresponding author: Graham Mayrhofer, graham.mayrhofer@.au Received: 19 Apr 2007 Revisions requested: 22 Jun 2007 Revisions received: 8 Oct 2007 Accepted: 20 Nov 2007 Published: 20 Nov 2007 Arthritis Research Therapy 2007, 9:R120 (doi:10.1186/ar2328) This article is online at: /content/9/6/R120 © 2007 Moghaddami et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Adoptive transfer of adjuvant-induced arthritis was used in this CD45+MHC IIhi cells constituted approximately half of all CD45+ study to examine local macrophages and dendritic cells (DCs) cells in SRT. Most of the MHC IIhi cells expressed