radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers an evaluation from 1 to 4 years after diagnosis射线在风湿性关节炎关节损伤与软骨的差异可以预测营业额和血清生物标志物评估诊断后从1到4年.pdfVIP

Available online /content/8/1/R31 Vol 8 No 1 Open Access Research article Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis 1 2 2 3 4 5 SMM Verstappen , AR Poole , M Ionescu , LE King , M Abrahamowicz , DM Hofman , 1 1 JWJ Bijlsma , FPJG Lafeber and the Utrecht Rheumatoid Arthritis Cohort Study group (SRU) 1Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands 2Joint Disease Laboratory, Shriners Hospital for Children, Departments of Surgery and Medicine, McGill University, Montreal, Canada 3IBEX Pharmaceuticals, Montreal, Canada 4Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada 5Department of Rheumatology, Hilversum Hospital, Hilversum, The Netherlands Corresponding author: SMM Verstappen, s.verstappen@azu.nl Received: 11 Jul 2005 Revisions requested: 22 Aug 2005 Revisions received: 28 Nov 2005 Accepted: 9 Dec 2005 Published: 10 Jan 2006 Arthritis Research Therapy 2006, 8:R31 (doi:10.1186/ar1882) This article is online at: /content/8/1/R31 © 2006 Verstappen et al.; licensee BioMed Central Ltd. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The objective of this study was to determine per year) wer